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The Detailed Information of Protein

Protein ID: ICDB_Pro_1711
Protein Name: Inositol 1;4;5-trisphosphate receptor itr-1
Function: Receptor for inositol 1;4;5-trisphosphate; a second messenger that regulates intracellular calcium homeostasis. Binds in vitro to both inositol 1;4;5-trisphosphate (1;4;5-InsP3) and inositol 2;4;5-trisphosphate (2;4;5-InsP3) with high affinity and does not discriminate between the phosphate at 1 or 2 position. Can also bind inositol 1;3;4;5-tetrakisphosphate (1;3;4;5-InsP4) and inositol 4;5-bisphosphate (4;5-InsP2); but with lower affinity. Acts as a timekeeper/rhythm generator via calcium signaling; affecting the defecation cycle and pharyngeal pumping. Affects normal hermaphrodite and male fertility as a participant in intracellular signaling by acting downstream of let-23/lin-3 which regulates ovulation; spermathecal valve dilation and male mating behavior. Important for early embryonic development; controls epidermal cell migration and may also regulate filopodial protrusive activity during epithelial morphogenesis. Component of inositol trisphosphate (IP3)-mediated downstream signaling pathways that controls amphid sensory neuronal (ASH)-mediated response to nose touch and benzaldehyde but not other ASH-mediated responses. Involved in modulating lifespan; acting downstream of transcription factor atf-6.
Sequence: MNPSYGRVRKKVSIISIPEFVPEHYEYENETTASGGASGGGSTRIEFDFDDFEEQIMRKSSMALPSRKLTIANSIDHGNNGNLHIGDIISLYTESSSNQEQRGFLSTLGLVDDRCIVELKDGRPESPPKKFRDCLFKVCPVNRYAAQKHLWTEQKRFQTGDSMFDDDLMNKLKVAADKEREENESEFQKTLGNVIQYGSMVQLLHVKSNKYITVQKNSPAKRERNAMKVYLDRAGNEGSWFIIEPAYKHYAIGDNVSAGNKISLIPNSVSTTQAGHVKSQLHLSSFNLLDHQSAAEVNCLNEPTEWQVFMFLLFDENQQNSVKSGDVVRLFHADQQTFLTLDTIPKQNPPTDVVFLRMTNRPSAADATSSRALWEVQVVQTNAYRGGTAKWNKAYRFKHLATDMYLSAEPSQVQVKPAMNGRRASLIYSKTNNPMAMYSDGPNGVTNESTDTTQQNIPSVWVLGPTKSEFPEEDANLLFQLDPSTFMKSNKEVPRRSYVRLLHQSSDKWVHATNATEKQNLHYSSKNEKGWVKVICEKNRVDKETFALLPVNPDEVRDLDFANDACKALRNFIKLIKIGQVISKESINSTTQLLIDCILFVTNSSDHLADPLKISDFSPSRDRQKLLREQEVLNQVFLLLKAPFLPRQGTTELGPLLSSPSELSDSRNEIFKTMFQLCYCLLKYSQVSYRKNQEFLAEKFGEIQEQIGFDLMAEDTMTAVLHNNPKLLEKYVKTPHVERFVELVRNNRQGKFLDYLADLCVCRGEANKKIQELICTSVLSSKHRDIFMDTKIIDGEIEVGWAPNFRKLVDIAEGAKSNSDDAEHLDYYRHQLDLLSQMCQEQQYLAIDPPPERRLMNISQQLPAELVLQCMSDNRLPYDLRGSFTRLMLHLHVVRGSPMSAIRHARLWWSIPENVNVSTYESVSVEAYSDGSRMRIGEGIAHKVLATVETYLMGLRNQSMEERQSVNSSKLTYEIVNLAKALAQFNFYSFNDLLQLTQNLLAIINEGPATEQVPSHRAMVNAIRNMSKSMMRGGNKENSKDLAKTPSVTAEEAGRTKEGRALNVKTKLIVAEILQFVMDVRRDYRITMALSWFKNVFPCDEDGSLMHSASINERMASELYDAIYRSSGHELHLDGRDGQLLLAILLQMTMSDYPPLTSIALKVFFRHFTQYQELLEDLKQVQLLVSNNDVENYRQIDRDLFILKNLTEKSELWVHGDRHHSIDTKEVDEKERTTEHDLLDHDLKSPRAFDSGDSMEALMAVLNEHYPSIRNECLQLLNRLLIKDDRNDAAVALQELSDKAPLIAYPLIRQMLVRLTGMCYRKGDPKPDTMNQQLLKNMRVYEVVLEFISVPHDKKHDHDMMKLITLSHEFLRSFCKTNKENQSRLYKFISYEKDAKEGMLRVETIEEVGTLVAIFRNNRELASNVPEELIAHIVGLIEHNSRNPIFLELLQALVCVYDKEIESGQEKVANEICAASDEVRQLYVDNASFEELEAMMKDEKESKGRSSDSRRKLKYHIELVRLLAMCTRGKNGNTELKCASQIPMDHIVRVVTAKQCLVEVKTVYLQLLLHCYIDTDAEMKDAYKTEYVDHILNNLLEDIRSLRVEKLTGAETATLEHYICHTVTEVLIKFFEAPYSALQQAKVDVHHHKKTFSEVLLELTYLEKGKLRGSKSSRNWYRVAECIKRLTKWAEEHNITLPATLAGPQMSGQTSVRQKWQQAASSAKWIGIGKRLNRQNTLNPGHRLYGTSNSMTEHTSANVVTCYHMMIGEFKFYLHPLHAAEGSVLVEVLHTPELLFPEGSALRDQCARGGVVAKLIQHCKTLMQNKQDNLCARVLQTLCKMCDCTKQQLTHQGQQLRQLLLQRYFGHHNNHHPPLDRQQSKIGEVIEAVKEKKEETWSQERDLYAIQCKLNDAGASDLVTDIIIMEPSREIFLKAIHLARALLHEGNDKVQHSFYMRMKQKDIHEPFFKAILTRIQTAQNRLKSDMMSCSDSKPKVSLSATVSRRSSTVLTPLIDAGDTGFNGALFEVPQQVRHPSISEMSQLSNDLTHSIPDLAPYQDEEKSTDALPPEVALVEPILRVLQLLCENHNSLLQNFLRKQSDRTNHNLVSETLSFLDTVCGSTKGSLGVFGEIGEHNFSLITQTLATLTEFCQGPCHENQNTMAMQENGLNIIISLVLNEIKPLADDHMELALEIKSQASKLLLAIMESRHDGENANRVLRNMANMSGGPKQLVHAIKQAYEMTNSNHHMLKSISRDLFRQAEDDLKKKSGPQITVNTVTLPEINVDASGIVSIHTEKNISSSLDDKFNDDDIPSVDPREVGHNIYILAHQLAIHDGELEIWLDGSDEKKDDLTREALNYYKERTAQIEIVRRDRTLERVVFPINDICSYLTKDTKDYVYNNTERDNQGSKVTEFFDEWETMYHEMIWQRKLQDRKWLSWCAFRLPLWTRLSFHFAFIVNALVARYYPLPEHSNSSISLGNLYSWFAVFSSFLLAHYLRHDKIYLHKTSLLILASLCFLLLSSIGVTLTLYIFGILQLVNKIVHVVAFVSNKGLEDRPIAEILACRNLHYLLVYLFICILGLLVHPMIYCILLFDIIFTEETLQNVIASVTRNYQSIVWTGLLALILLYFFSILGFLYFRHDFYLEVDPVENDSSATISSGIPSETCPSEGCPGLQPSEKDDNDDEKKVKSCETLWMCILQTGYQGLRNGGGIGDVLRNPAPWEDMFIWRVAYDMTFFVVLIVIVLNLIFGVIIDTFGDLRAEKNEKEQILKNNCFICGLDRSRFDNRSVTFETHRETEHNIWHYLYYIVMLQIKDETEFTGPESYVAQCVKDRNLDWFPRMQALSLQDSELDTDQSEVKQMKDQLLQMMTLMREIISQNEESRAFMEQFQPR
Gene Name: itr-1; dec-4; lfe-1; F33D4.2
Organism: Caenorhabditis elegans
Length: 2892
PDB:
Ligand Binding:
AlphaFoldDB: AF--F1-model_v4.pdb
Binding site: 357..361;625..628;689..691;
Disease:
Location: Isoform a is expressed in the anterior cells of the pharyngeal terminal bulb; vulva; rectal epithelial cells; spicule protractor muscles of the proctodeum and male-specific neuron CP8 or CP9. Isoform d is expressed in the spermatheca; excretory cell; amphid socket cells; PDA motor neuron; spicule retractor muscles; gubernaculum retractor muscles; posterior oblique muscles; diagonal muscles and the vas deferens. Also expressed in the intestine; pharynx; pharyngeal isthmus; pharyngeal intestinal valve; somatic gonad; hypodermal cells of the vulva; uterine sheath cells; tail; head; LUA motor neuron and the embryonic epidermis (at protein level). Also expressed in the intestine; pharynx; pharyngeal isthmus; pharyngeal intestinal valve; somatic gonad; hypodermal cells of the vulva; uterine sheath cells; tail; head; LUA motor neuron and the embryonic epidermis (at protein level). Also expressed in the intestine; pharynx; pharyngeal isthmus; pharyngeal intestinal valve; somatic gonad; hypodermal cells of the vulva; uterine sheath cells; tail; head; LUA motor neuron and the embryonic epidermis (at protein level).
DOI ID: 10.1016/s0092-8674(00)81510-x; 10.1006/jmbi.1999.3229; 10.1126/science.282.5396.2012; 10.1016/s0092-8674(00)80945-9; 10.1006/jmbi.2000.4388; 10.1091/mbc.12.9.2835; 10.1016/s0960-9822(02)00868-0; 10.1091/mbc.01-08-0422; 10.1016/j.cub.2004.10.001; 10.1016/s0014-5793(04)00107-3; 10.1091/mbc.e04-01-0039; 10.1091/mbc.e04-03-0198; 10.1242/dev.02083; 10.1085/jgp.200509355; 10.1091/mbc.e05-02-0096; 10.1371/journal.pgen.1000043; 10.1371/journal.pgen.1000636; 10.1007/s10059-011-0007-9; 10.1371/journal.pgen.1003510; 10.1016/j.celrep.2020.108125
RefSeq: NP_001023170.1 [Q9Y0A1-1]; NP_001023171.1 [Q9Y0A1-2]; NP_001023172.1 [Q9Y0A1-3]; NP_001023173.1 [Q9Y0A1-4]; NP_001023174.1; NP_001255305.1 [Q9Y0A1-6]